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KMID : 0368819960350051459
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Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 5 p.1459 ~ p.1466
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Dexamethasone Suppresion Test in Patients with Combat-related Postraumtic Stress Disorder
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정혜경
정문용/정용진
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Abstract
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In order to investigate the possibility of enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal axis, we used dexamethasone suppression test in 12 male posttraumatic stress disorder patients and age matched 12 male
controls.
We
also measured Mississippi scale and Beck depression inventory(BDI),which were significantly higher in patient group than in control group. There was no difference in combat exposure scale(CES) score and baseline plasma cortisol level between
patient
group and control group. Plasma cortisol levels at 8:00 a. m. and 4:00 p. m. were significantly lower in patient group than control group. Relative value of change was significantly higher in patient group than in control group.
There was no significant correlation between relative value of change of cortisol from baseline to 4:00 p. m. and BDI and CES sores. But Mississippi scale had significant correlation with relative value of change.
It is supposed that alteration of DST observed in this study be related with enhanced HPA axis sensitivity in posttraumatic stress disorder.
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KEYWORD
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